The purpose of this manual is to inform mental health professionals about significant clinical issues that arise when working with TGNC individuals. This manual is not a rigid set of guidelines or standards for care and does not in any way replace treatment protocols. It intends to only complement treatment guidelines for TGNC individuals. The manual is focused solely in TGNC population. It includes a set of definitions for readers who may be less familiar with the language used when discussing TGNC issues, most common issues and challenges faced in therapy.